Hydrazine hydrate (1:1) → HCID 19610610, compound

HRID 1602258Notes

Reaction equation

HRID 1602258 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](SC)=[C:13]([C:16]#[N:17])[C:14]#[N:15])=[CH:7][CH:6]=1)(=O)[CH3:2].[OH2:20].[NH2:21][NH2:22]>CO>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:13]([C:14]#[N:15])=[C:16]([NH2:17])[NH:22][N:21]=2)=[CH:7][CH:6]=1)(=[O:20])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 1704474HCID 1704474, compound

Product 1

HCID 19610610HCID 19610610, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 7.46 g (27.4 mmol) of 3-(4-acetylamino-phenylamino)-2-cyano-3-methylmercapto-acrylonitrile, 1.63 ml (32.9 mmol) of hydrazine hydrate and 40 ml of methanol is heated under reflux for 5 hours and then concentrated by evaporation in vacuo. Recrystallization of the residue from methanol yields the title compound; m.p. 245-246° C. (decomp.).

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 5 hours
  3. concentrationconcentrated by evaporation in vacuo
  4. customRecrystallization of the residue from methanol

Sources & evidence

ORD record
ord-901022e0a2df483eb597e6c6cc203516
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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