Hydrazine hydrate (1:1) → HCID 10633989, compound

HRID 1602265Notes

Reaction equation

HRID 1602265 reaction equation
[C:1]([C:3](=[C:6]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)SC)[C:4]#[N:5])#[N:2].O.[NH2:20][NH2:21]>CO>[NH2:2][C:1]1[NH:21][N:20]=[C:6]([NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[C:3]=1[C:4]#[N:5]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19610575HCID 19610575, compound

Product 1

HCID 10633989HCID 10633989, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 15 g (57.8 mmol) of 2-cyano-3-(4-methoxy-benzylamino)-3-methylmercapto-acrylonitrile, 3.03 ml (61.1 mmol) of hydrazine hydrate and 40 ml of methanol is stirred for 1 hour at RT, heated under reflux for 2 hours and then concentrated by evaporation in vacuo. Recystallization of the residue from ethanol/hexane yields the title compound; m.p. 148-149° C.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 2 hours
  3. concentrationconcentrated by evaporation in vacuo

Sources & evidence

ORD record
ord-ea37bd5580f043078caea1bf6d10a1c3
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

Loading…