反应详情

A mixture of 15 g (60.1 mmol) of 3-(3-chloro-phenylamino)-2-cyano-3-methylmercapto-acrylonitrile [for preparation see: EP 0 010 396 A1], 3.13 ml (63.2 mmol) of hydrazine hydrate and 100 ml of methanol is heated under reflux for 3 hours and then concentrated by evaporation in vacuo. Recrystallization of the residue from ethyl acetate/hexane yields the title compound; m.p. 195-200° C.

1. temperatureis heated
2. temperatureunder reflux for 3 hours
3. concentrationconcentrated by evaporation in vacuo
4. customRecrystallization of the residue from ethyl acetate/hexane