Sodium Hydroxide → HCID 5327837, compound

HRID 1602278Notes

Reaction equation

HRID 1602278 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([N:9]2[C:14](=[NH:15])[C:13]3[C:16]([NH:19][CH2:20][C:21]4[CH:26]=[CH:25]C=C(OC)[CH:22]=4)=[N:17][NH:18][C:12]=3[N:11]=[CH:10]2)[CH:6]=[CH:7][CH:8]=1.O1[CH2:34][CH2:33][O:32][CH2:31]C1.[OH-].[Na+]>O>[Cl:2][C:3]1[CH:4]=[C:5]([NH:9][C:14]2[N:15]=[CH:10][N:11]=[C:12]3[NH:18][N:17]=[C:16]([NH:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:34]=[C:33]([O:32][CH3:31])[CH:22]=4)[C:13]=23)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 135772615HCID 135772615, compound2×

Product 1

HCID 5327837HCID 5327837, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
5 °C

Procedure

A mixture of 0.417 g (1 mmol) of 5-(3-chloro-phenyl)-1,5-dihydro-4-imino-3-(3-methoxy-benzylamino)-4H-pyrazolo[3,4-d]pyrimidine hydrochloride (Example 45, title compound II), 20 ml of dioxane, 19 ml of water and 1 ml of 1N sodium hydroxide solution is heated under reflux for 10 hours. Cooling to approx. 5° C., filtering, washing the filter residue with water and drying under a HV at 120° C. yield the title compound (see Example 45); m.p. 192-193° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 10 hours
  3. filtrationfiltering
  4. washwashing the filter residue with water
  5. customdrying under a HV at 120° C.

Sources & evidence

ORD record
ord-9f9561bcde9b4cab80437cc712a6b437
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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