Sodium Hydroxide → HCID 5327837, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.417 g (1 mmol) of 5-(3-chloro-phenyl)-1,5-dihydro-4-imino-3-(3-methoxy-benzylamino)-4H-pyrazolo[3,4-d]pyrimidine hydrochloride (Example 45, title compound II), 20 ml of dioxane, 19 ml of water and 1 ml of 1N sodium hydroxide solution is heated under reflux for 10 hours. Cooling to approx. 5° C., filtering, washing the filter residue with water and drying under a HV at 120° C. yield the title compound (see Example 45); m.p. 192-193° C.

Provenance & Evidence