Formic Acid → HCID 178489914, compound

HRID 1602280Notes

Reaction equation

HRID 1602280 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)[C:3]=1[C:22]#[N:23].[CH:24](O)=O.[OH2:27]>>[CH2:7]([N:6]1[C:2]2=[N:1][CH:24]=[N:23][C:22]([OH:27])=[C:3]2[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)=[N:5]1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 284Formic AcidHCID 962WaterHCID 10518610HCID 10518610, compound

Product 1

HCID 178489914HCID 178489914, compound

Procedure

A mixture of 2.55 g (8.38 mmol) of 5-amino-1-benzyl-4-cyano-3-(3-methoxy-phenyl)-pyrazole and 20 ml of 85% aqueous formic acid is heated under reflux for 21 hours and then cooled to room temperature and, with stirring, a small amount of water is added thereto. Filtering and washing the filter residue with water yield the title compound; m.p. 183-185° C.; FAB-MS: (M+H)+ =333.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 21 hours
  3. filtrationFiltering
  4. washwashing the filter residue with water

Sources & evidence

ORD record
ord-c430eb106a14405c8e172d1b7948c9fd
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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