Dimethylformamide diethylacetal → HCID 53771203, compound

HRID 1602289Notes

Reaction equation

HRID 1602289 reaction equation
[C:1]([NH:4][C:5]1[CH:20]=[CH:19][C:8]([CH2:9][NH:10][C:11]2[C:15]([C:16]#[N:17])=[C:14]([NH2:18])[NH:13][N:12]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(O[CH:24](OCC)[N:25]([CH3:27])[CH3:26])C>C1(C)C=CC=CC=1>[C:1]([NH:4][C:5]1[CH:20]=[CH:19][C:8]([CH2:9][NH:10][C:11]2[C:15]([C:16]#[N:17])=[C:14]([N:18]=[CH:24][N:25]([CH3:27])[CH3:26])[NH:13][N:12]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 70913Dimethylformamide diethylacetalHCID 19610602HCID 19610602, compound

Product 1

HCID 53771203HCID 53771203, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of 0.48 g (1.4 mmol) of 3-(4-acetylamino-benzylamino)-5-amino-4-cyano-pyrazole containing 21.06% THF, 0.245 ml (1.43 mmol) of N,N-dimethylformamide diethyl acetal and 4 ml of toluene is heated under reflux for 4.5 hours. The reaction mixture is then cooled to approx. 0° C. and filtered and the filter residue is washed with toluene, yielding the title compound; m.p. 206-211° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 4.5 hours
  3. filtrationfiltered
  4. washthe filter residue is washed with toluene

Sources & evidence

ORD record
ord-07e9ad045d1247b28418b5bbcda3dffa
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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