Sodium Hydroxide → HCID 178419339, compound

HRID 1602318Notes

Reaction equation

HRID 1602318 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)=O)=O)=[CH:4][CH:3]=1.[NH:19]([C:23]1[NH:24][C:25]2[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=2[N:27]=1)[C:20]([NH2:22])=[NH:21].[OH-].[Na+]>CO.O>[N:27]1[C:26]2[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=2[NH:24][C:23]=1[N:19]=[C:20]1[NH:22][C:8]2([C:5]3[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=3)[NH:22][C:20](=[N:19][C:23]3[NH:27][C:26]4[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=4[N:24]=3)[NH:21][C:10]2([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)[NH:21]1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 964304,4'-DibromobenzilHCID 1785125941-(1H-benzimidazol-2-yl)guanidine

Product 1

HCID 178419339HCID 178419339, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Following the procedure of Example 1, 4,4'-dibromobenzil (4.42 g, 12 mmol) and 2-guanidinobenzimidazole (1.75 g, 10 mmol) in methanol (100 mL) was treated with a solution of sodium hydroxide (400 mg, 10 mmol) in 10 mL of water. The title compound was isolated as pale yellow crystals (800 mg, 24% yield). mp: 274-278 ° C. (dec); MS (ESI) m/z 683 [M+H]+.

Sources & evidence

ORD record
ord-bcf3c3e075aa49b593d3977e8c5e0d17
Source dataset
uspto-grants-1999_11
Patent number
US05981551

Reaction notes

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