HCID 15663660, compound → HCID 19610888, compound

HRID 1602336Notes

Reaction equation

HRID 1602336 reaction equation
[N:1]1[N:2]([C:6]23[CH2:13][N:10]([CH2:11][CH2:12]2)[CH2:9][CH2:8][CH2:7]3)[N:3]=[N:4][CH:5]=1.[Br:14]C1NN=NN=1>>[Br:14][C:5]1[N:4]=[N:3][N:2]([C:6]23[CH2:13][N:10]([CH2:11][CH2:12]2)[CH2:9][CH2:8][CH2:7]3)[N:1]=1

Participants

3

Reactant 2

HCID 15663660HCID 15663660, compoundHCID 178419492HCID 178419492, compound

Product 1

HCID 19610888HCID 19610888, compoundYield 56%

Procedure

5-(Tetrazol-2-yl)-1-azabicyclo[3.2.1]octane (the free base of E29) (0.2 g, 1.12 mmol) was converted to the 5-bromotetrazole according to the method of Example 40. Chromatography on silica using 4% methanol/chloroform afforded the title compound (E50) as a white crystalline solid (0.16 g, 56%) m.p. 108-110° C.

Sources & evidence

ORD record
ord-9817e9d877504814a86c60f55debf3e8
Source dataset
uspto-grants-1999_11
Patent number
US05981545

Reaction notes

Loading…