Potassium Carbonate → HCID 67595031, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine	HCID 2733845	—
Reactant	4,5-Bis(bromomethyl)-1,3-dioxol-2-one	HCID 12325849	—
Solvent	Acetonitrile	HCID 6342	—
Product	HCID 67595031	HCID 67595031	18%

Reaction Conditions

Temperature	25 °C

Reaction Steps

4,5-Dibromomethyl-2-oxo-1,3-dioxolene (188 mg, 0.69 mmol) was dissolved in acetonitrile (5.0 mL). Thereto were added 2-(N-Boc-amino)isobutyric acid (70 mg, 0.35 mmol) and potassium carbonate (48 mg, 0.35 mmol). This mixture was stirred at 25° C. for 18 hours. After the ordinary post-treatment, the reaction product was purified by thin-layer chromatography (developed with chloroform) to obtain Compound S-33 (50 mg, yield 18%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05981558
Source dataset	uspto-grants-1999_11
ORD ID	ord-567e597ddbc3437d8b18aa85eb7cb68b
Source note	uspto-grants-1999_11