Potassium Carbonate → HCID 67595031, compound

HRID 1602362Notes

Reaction equation

HRID 1602362 reaction equation
Br[CH2:2][C:3]1[O:4][C:5](=[O:10])[O:6][C:7]=1[CH2:8][Br:9].[C:11]([NH:18][C:19]([CH3:24])([CH3:23])[C:20]([OH:22])=[O:21])([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:9][CH2:8][C:7]1[O:6][C:5](=[O:10])[O:4][C:3]=1[CH2:2][O:22][C:20](=[O:21])[C:19]([NH:18][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])([CH3:24])[CH3:23]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2733845N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanineHCID 123258494,5-Bis(bromomethyl)-2H-1,3-dioxol-2-one

Product 1

HCID 67595031HCID 67595031, compoundYield 18%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
25 °C

Procedure

4,5-Dibromomethyl-2-oxo-1,3-dioxolene (188 mg, 0.69 mmol) was dissolved in acetonitrile (5.0 mL). Thereto were added 2-(N-Boc-amino)isobutyric acid (70 mg, 0.35 mmol) and potassium carbonate (48 mg, 0.35 mmol). This mixture was stirred at 25° C. for 18 hours. After the ordinary post-treatment, the reaction product was purified by thin-layer chromatography (developed with chloroform) to obtain Compound S-33 (50 mg, yield 18%).

Workup

  1. customAfter the ordinary post-treatment, the reaction product was purified by thin-layer chromatography (developed with chloroform)
  2. customto obtain Compound S-33 (50 mg, yield 18%)

Sources & evidence

ORD record
ord-567e597ddbc3437d8b18aa85eb7cb68b
Source dataset
uspto-grants-1999_11
Patent number
US05981558

Reaction notes

Loading…