反应详情

温度

0 °C

Combine t-butyl diethylphosphonodibromoacetate (75.6 g, 184 mmol) and isopropanol (190 mL). Cool to 0° C. Add a solution of tin (II) chloride (33.2 g, 175 mmol) in water (190 mL). After the addition is complete, warm to ambient temperature. After 1 hour, extract the reaction mixture three times with chloroform. Combine the organic layers and extract with water, dry over MgSO4, filter, and evaporate in vacuo to give the title compound.

1. additionAfter the addition
2. temperaturewarm to ambient temperature
3. extractionextract the reaction mixture three times with chloroform
4. extractionextract with water
5. dry with materialdry over MgSO4
6. filtrationfilter
7. customevaporate in vacuo