反应详情

A solution of (E)-3-(7-fluoro-benzofuran-4-yl)-acrylonitrile (0.25 g) in ethanol (25 ml), ammonia (0.88; 10 ml) containing 10% palladium on charcoal (50 mg; 50% wet paste) and 5% rhodium on charcoal (50 mg) was hydrogenated at 70 psi and 70° for 18 h. The solution was filtered through hyflo and evaporated to dryness and the residue purified by column chromatography. Eluting with dichloromethane/ethanol/ammonia 100:8:1 gave the title compound (256 mg).

1. filtrationThe solution was filtered through hyflo
2. customevaporated to dryness
3. customthe residue purified by column chromatography
4. washEluting with dichloromethane/ethanol/ammonia 100:8:1