反应详情

A mixture of 4-fluoro-3-methylphenol (36.7 g), potassium hydroxide pellets (19.5 g) and bromoacetaldehyde dimethyl acetal (34.6 ml) in dimethyl sulphoxide (240 ml) was heated at 110° for 24 h. The mixture was cooled, diluted with water (350 ml) and extracted with hexane. Evaporation of the extracts gave the title compound as an oil (52.3 g).

1. temperaturewas heated at 110° for 24 h
2. temperatureThe mixture was cooled
3. extractionextracted with hexane
4. customEvaporation of the extracts