HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 1-(2,2-Dimethoxyethoxy)-4-fluoro-3-methylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-Bromo-1,1-dimethoxyethane | HCID 81672 | — |
| Reactant | 4-Fluoro-3-methylphenol | HCID 2737394 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(2,2-Dimethoxyethoxy)-4-fluoro-3-methylbenzene | HCID 19611659 | — |
Reaction Steps
A mixture of 4-fluoro-3-methylphenol (36.7 g), potassium hydroxide pellets (19.5 g) and bromoacetaldehyde dimethyl acetal (34.6 ml) in dimethyl sulphoxide (240 ml) was heated at 110° for 24 h. The mixture was cooled, diluted with water (350 ml) and extracted with hexane. Evaporation of the extracts gave the title compound as an oil (52.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05981572 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-97012483233c4b518f4a00abe00edd50 |
| Source note | uspto-grants-1999_11 |