Hydrochloric Acid → HCID 19611685, compound

HRID 1602403Notes

Reaction equation

HRID 1602403 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[C:10]=1[CH2:11][CH2:12][CH2:13][NH:14]C(=O)C.[ClH:18]>>[ClH:18].[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[C:10]=1[CH2:11][CH2:12][CH2:13][NH2:14]

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 19611697HCID 19611697, compound

Product 1

HCID 19611685HCID 19611685, compound

Procedure

N-[3-[2,3-Dihydro-5-fluorobenzofuran-4-yl]propyl]acetamide (0.55 g) was heated under reflux in 2M hydrochloric acid (10 ml) for 24 h. The mixture was cooled and washed with dichloromethane, basified with 2M sodium hydroxide and extracted with dichloromethane. Evaporation of the extracts gave an oil which was dissolved in 0.7M methanolic hydrogen chloride (8 ml). Evaporation gave the title compound as a beige solid (0.28 g).

Workup

  1. temperatureThe mixture was cooled
  2. washwashed with dichloromethane
  3. extractionextracted with dichloromethane
  4. customEvaporation of the extracts
  5. customgave an oil which
  6. customEvaporation

Sources & evidence

ORD record
ord-b48d778870094403815b84d4286d9c35
Source dataset
uspto-grants-1999_11
Patent number
US05981572

Reaction notes

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