HCID 44214323, compound → HCID 44214324, compound

HRID 1602420Notes

Reaction equation

HRID 1602420 reaction equation
C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4].[Cl:18][C:19]1[CH:20]=[C:21]([F:37])[C:22]2[O:26][CH2:25][CH2:24][C:23]=2[C:27]=1[CH2:28][CH2:29][CH2:30][NH:31][C:32]([CH:34]1[CH2:36][CH2:35]1)=[O:33]>C(O)(=O)C>[Cl:18][C:19]1[CH:20]=[C:21]([F:37])[C:22]2[O:26][CH:25]=[CH:24][C:23]=2[C:27]=1[CH2:28][CH2:29][CH2:30][NH:31][C:32]([CH:34]1[CH2:36][CH2:35]1)=[O:33]

Participants

4

Reactant 2

HCID 44214323HCID 44214323, compoundHCID 178418268HCID 178418268, compound

Product 1

HCID 44214324HCID 44214324, compoundYield 10.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Lead tetraacetate (313 mg) was added to a solution of cyclopropanecarboxylic acid [3-(5-chloro-7-fluoro-2,3-dihydro-benzofuran-4-yl)-propyl]-amide (0.2 g) in glacial acetic acid (5 ml) and the mixture stirred at room temperature for 18 h. The solvent was evaporated and the resdue purified by preparitive HPLC to give the title compound as a colourless solid (20 mg).

Workup

  1. customThe solvent was evaporated
  2. customthe resdue purified by preparitive HPLC

Sources & evidence

ORD record
ord-d9d3f63e4ab04475bcc367cc0f9eaf78
Source dataset
uspto-grants-1999_11
Patent number
US05981572

Reaction notes

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