HCID 44214321, compound → HCID 44214325, compound

HRID 1602422Notes

Reaction equation

HRID 1602422 reaction equation
C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4].[O:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[C:26]([CH2:27][CH2:28][CH2:29][NH:30][C:31]([CH:33]3[CH2:35][CH2:34]3)=[O:32])[C:21]=2[CH2:20][CH2:19]1>C(O)(=O)C>[O:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[C:26]([CH2:27][CH2:28][CH2:29][NH:30][C:31]([CH:33]3[CH2:34][CH2:35]3)=[O:32])[C:21]=2[CH:20]=[CH:19]1

Participants

4

Reactant 2

HCID 44214321HCID 44214321, compoundHCID 178418268HCID 178418268, compound

Product 1

HCID 44214325HCID 44214325, compoundYield 15.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Lead tetraacetate (194 mg) was added to a solution of cyclopropanecarboxylic acid [3-(2,3-dihydro-benzofuran-4-yl)-propyl]-amide (100 mg) in acetic acid (1.5 ml) at 10°. The mixture was stirred at room temperature for 4 h and at 50° for 24 h. The solvent was evaporated and the residue purified by chromatography on silica. Elution with hexane/ethyl acetate gave the title compound as an oil (15 mg).

Workup

  1. customThe solvent was evaporated
  2. customthe residue purified by chromatography on silica
  3. washElution with hexane/ethyl acetate

Sources & evidence

ORD record
ord-893ed6d228a449a3b4276cafe78b6e6d
Source dataset
uspto-grants-1999_11
Patent number
US05981572

Reaction notes

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