Water → 4-Chloroisatoic anhydride

HRID 1602589Notes

Reaction equation

HRID 1602589 reaction equation
[OH2:1].[C:2]1(C)C=CC=CC=1.[Cl:9][C:10]1[CH:11]=[C:12]([NH2:19])[C:13](=[CH:17][CH:18]=1)[C:14]([OH:16])=[O:15]>O1CCCC1>[CH:18]1[C:10]([Cl:9])=[CH:11][C:12]2[NH:19][C:2]([O:15][C:14](=[O:16])[C:13]=2[CH:17]=1)=[O:1]

Participants

5

Reactant 3

HCID 962Water2×HCID 1140TolueneHCID 666462-Amino-4-chlorobenzoic acid

Product 1

HCID 3291054-Chloroisatoic anhydrideYield 93%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

According to the same manner as in Example 5, except that 171.6 g of water and 171.6 g of toluene were used in place of 78.9 g of water and 315.5 g of tetrahydrofuran, and that 4-chloroanthranilic acid was used in place of 4,5-dimethoxyanthranilic acid, 80.9 g of 7-chloroisatoic anhydride (purity: 91%) was obtained.

Sources & evidence

ORD record
ord-827084c28ce945008f5b476e82abd65e
Source dataset
uspto-grants-1999_11
Patent number
US05981749

Reaction notes

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