Hydrochloric Acid → HCID 22008800, compound

HRID 1602615Notes

Reaction equation

HRID 1602615 reaction equation
[O:1]=[C:2]1[CH:7]([CH2:8][CH2:9][C:10]2[CH:19]=[CH:18][C:17]3[CH2:16][CH2:15][CH2:14][NH:13][C:12]=3[N:11]=2)[CH2:6][CH2:5][CH2:4][N:3]1[CH2:20][C:21]([O:23]CC)=[O:22].Cl>>[O:1]=[C:2]1[CH:7]([CH2:8][CH2:9][C:10]2[CH:19]=[CH:18][C:17]3[CH2:16][CH2:15][CH2:14][NH:13][C:12]=3[N:11]=2)[CH2:6][CH2:5][CH2:4][N:3]1[CH2:20][C:21]([OH:23])=[O:22]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22008742HCID 22008742, compound

Product 1

HCID 22008800HCID 22008800, compound

Procedure

A solution of 1-7 (71 mg, 0.21 mmol) and 6N HCl (15 mL) was stirred at 55° C. for 2 h, followed by concentration to give 1-8 as a pale yellow gum. TLC Rf =0.09 (silica, 20% CH3OH/EtOAc)

Workup

  1. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-c2d20ed130414fc998b2e04e1ff4cd37
Source dataset
uspto-grants-1999_11
Patent number
US05981546

Reaction notes

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