Hydrochloric Acid → HCID 86754155, compound

HRID 1602630Notes

Reaction equation

HRID 1602630 reaction equation
[ClH:1].[I:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:12][C@H:13]([C:16]([OH:18])=[O:17])[CH2:14][NH2:15])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH3:19][CH2:20]O>>[ClH:1].[CH2:19]([NH:15][CH2:14][C@H:13]([NH:12][S:9]([C:6]1[CH:5]=[CH:4][C:3]([I:2])=[CH:8][CH:7]=1)(=[O:11])=[O:10])[C:16]([OH:18])=[O:17])[CH3:20]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 10547108HCID 10547108, compound

Product 1

HCID 86754155HCID 86754155, compound

Conditions

Temperature
60 °C

Procedure

HCl gas was rapidly bubbled through a suspension of acid 8-3 (4.0 g, 10.81 mmol) in EtOH (50 ml) at 0° C. for 10 minutes. The cooling bath was removed and the reaction was heated to 60° C. After 18 h, the reaction was concentrated to provide ester 8-4 as a white solid.

Workup

  1. customThe cooling bath was removed
  2. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-c7d15e54d7404cb68da7e47519da8ba7
Source dataset
uspto-grants-1999_11
Patent number
US05981546

Reaction notes

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