Hydrochloric Acid → HCID 69370769, compound

HRID 1602631Notes

Reaction equation

HRID 1602631 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][C:10]2[CH:20]=[CH:19][C:13]([C:14]([O:16]CC)=[O:15])=[CH:12][CH:11]=2)[N:3]=1.[ClH:21]>>[ClH:21].[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:14]([OH:16])=[O:15])=[CH:19][CH:20]=2)[N:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 15887320HCID 15887320, compound

Product 1

HCID 69370769HCID 69370769, compound

Conditions

Temperature
60 °C

Procedure

A suspension of ester 8-5 (625 mg, 2.31 mmol) in 6N HCl (12 ml) was heated to 60° C. After ~20 h, the reaction was concentrated to give acid 8-6 as a tan solid.

Workup

  1. waitAfter ~20 h
  2. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-f816b357b5fa49b6afad43025bc88a45
Source dataset
uspto-grants-1999_11
Patent number
US05981546

Reaction notes

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