Hydrochloric Acid → HCID 70226631, compound

HRID 1602646Notes

Reaction equation

C([O:3][C:4](=[O:31])[CH2:5][N:6]1[C@H:10]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:9][C@H:8]([CH2:18][CH2:19][C:20]2[CH:29]=[CH:28][C:27]3[CH2:26][CH2:25][CH2:24][NH:23][C:22]=3[N:21]=2)[C:7]1=[O:30])C.[ClH:32]>>[ClH:32].[CH2:11]([C@H:10]1[N:6]([CH2:5][C:4]([OH:31])=[O:3])[C:7](=[O:30])[C@@H:8]([CH2:18][CH2:19][C:20]2[CH:29]=[CH:28][C:27]3[CH2:26][CH2:25][CH2:24][NH:23][C:22]=3[N:21]=2)[CH2:9]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 54145684HCID 54145684, compound

Product 1

HCID 70226631HCID 70226631, compound

Conditions

Temperature: 60 °C

Procedure

A mixture of 12-7 (150 mg, 0.3559 mmol) and 6N HCl (10 mL) was heated at 60° C. for 1 h. Evaporative removal of the solvent gave 12-8 as a yellow solid.

Workup

customEvaporative removal of the solvent

Sources & evidence

ORD record: ord-8385c5bf640841bf8a3b45995f3fae73
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05981546

Reaction notes

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