Oxalyl chloride → HCID 19612334, compound

Participants

Reaction Steps

In this example the product was prepared in two synthetic steps. In the first step 3-t-butylperoxy-1,3-dimethylbutanol was reacted with 100% molar excess of oxalyl chloride. Upon completion of the reaction the excess oxalyl chloride was stripped from the product at reduced pressure to produce 3-t-butylperoxy-1,3-dimethylbutyl chlorooxalate having an assay of 98.1% and in a corrected yield of 98.4%. In the second step 3-t-butylperoxy-1,3-dimethylbutyl chlorooxalate was reacted with 3-hydroperoxy-1,3-dimethylbutanol in the presence of pyridine to yield the product as described below:

Provenance & Evidence