2-Methoxy-4-nitro-1,1'-biphenyl → 56970-24-2

HRID 1602788Notes

Reaction equation

HRID 1602788 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:8]([O:10][CH3:11])[CH:9]=1)([O-])=O.[H][H]>[Pd].C(OCC)(=O)C>[CH3:11][O:10][C:8]1[CH:9]=[C:4]([CH:5]=[CH:6][C:7]=1[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[NH2:1]

Participants

5

Reactant 2

HCID 147748372-Methoxy-4-nitro-1,1'-biphenylHCID 178418361HCID 178418361, compound

Product 1

HCID 52177356970-24-2Yield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

2.6 g of 10% by weight of palladium on charcoal is added to a solution of 11.2 g of the product obtained in Stage A in 150 ml of ethyl acetate. The suspension obtained is agitated under 1.3 atmospheres of hydrogen. After the absorption of hydrogen has stopped, the reaction medium is returned to normal atmospheric pressure, followed by filtration and evaporation under reduced pressure in order to obtain 9.64 g of sought product melting at 56° C.

Workup

  1. customThe suspension obtained
  2. customAfter the absorption of hydrogen
  3. filtrationfollowed by filtration and evaporation under reduced pressure in order

Sources & evidence

ORD record
ord-835da54cf381482f8f76e68d2490136d
Source dataset
uspto-grants-1999_11
Patent number
US05985853

Reaction notes

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