反应详情

1 g of 5-bromo 2-chloro anisole and 0.66 g of N-chloro succinimide in 10 ml of acetic acid is heated at 90° C. for 20 hours. The reaction medium is poured into water, extraction is carried out with methylene chloride. The organic phase is washed with a saturated aqueous solution of sodium bicarbonate, dried over magnesium sulphate and evaporated under reduced pressure. 1.15 g of sought product is obtained.

1. washThe organic phase is washed with a saturated aqueous solution of sodium bicarbonate
2. dry with materialdried over magnesium sulphate
3. customevaporated under reduced pressure