HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Donepezil Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Donepezil Hydrochloride | HCID 5741 | 88.5% |
Reaction Steps
1.0 g of Donepezil was almost dissolved in 9 ml of DMSO at 20° C. 0.31 g of Concentrated hydrochloric acid in 1 ml of DMSO was added hereinto. After stirring for 1 hour at room temperature, 30 ml of TBME was added hereinto. It continued stirring over night at room temperature. Filtration of the separated crystals followed by drying afforded 0.97 g of the title compound. (water content: 0.25%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05985864 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-960d8b7761b44361a874c0cc7eb20ee0 |
| Source note | uspto-grants-1999_11 |