Hydrochloric Acid → Donepezil Hydrochloride

HRID 1602843Notes

Reaction equation

HRID 1602843 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:18][CH2:17]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:21]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 3152Donepezil

Product 1

HCID 5741Donepezil HydrochlorideYield 82.1%

Conditions

Temperature
22 °C

Procedure

2.0 g of Donepezil was dissolved in the mixture comprising from 0.65 g of concentrated hydrochloric acid and 10 ml of ion exchange purified water under stirring at 22° C. After stirring at room temperature for 1 hour, filtration of the separated crystals followed by drying afforded 1.80 g of the title compound. (water content: 11.00%)

Workup

  1. custompurified water
  2. stirringAfter stirring at room temperature for 1 hour
  3. filtrationfiltration of the separated crystals
  4. customby drying

Sources & evidence

ORD record
ord-152f6c58aaa34a35b238b85c11850cca
Source dataset
uspto-grants-1999_11
Patent number
US05985864

Reaction notes

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