Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Product | Donepezil Hydrochloride | HCID 5741 | 96.7% |
Reaction Steps
1.0 g of Donepezil was dissolved in the mixture comprising from 0.31 g of concentrated hydrochloric acid and 4 ml of ion exchange purified water under stirring at 22° C. 100 ml of THF was added hereinto. It continued stirring for 30 minutes at room temperature. Filtration of the separated crystals followed by drying afforded 1.06 g of the title compound. (water content: 11.14%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05985864 |
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| Source dataset | uspto-grants-1999_11 |
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| ORD ID | ord-b1b1f58d082345d590b7c72baa367f4c |
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| Source note | uspto-grants-1999_11 |
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