Hydrochloric Acid → Donepezil Hydrochloride

HRID 1602846Notes

Reaction equation

HRID 1602846 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:18][CH2:17]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]>CCCCCC>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:21]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3152Donepezil

Product 1

HCID 5741Donepezil HydrochlorideYield 148.1%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent2×

Procedure

1.0 g of Donepezil was dissolved in 9 ml of n-hexane at 21° C. 0.31 g of Concentrated hydrochloric acid in 1 ml of n-hexane was added hereinto. It continued stirring over night at room temperature. Filtration of the separated crystals followed by drying afforded 1.623 g of the title compound. (water content: 11.24%)

Workup

  1. filtrationFiltration of the separated crystals
  2. customby drying

Sources & evidence

ORD record
ord-63e5e93ac5c84ffa8326a8e488e80324
Source dataset
uspto-grants-1999_11
Patent number
US05985864

Reaction notes

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