Hydrochloric Acid → 2-{4-[4-(4-chlorobenzoyl)benzyl]-3,5-dichlorophenyl}-4,5-dihydro-1,2,4-triazin-3(2H)-one

HRID 1602884Notes

Reaction equation

HRID 1602884 reaction equation
[CH:1](=[N:8][N:9]([C:19]1[CH:24]=[C:23]([Cl:25])[C:22]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([C:33](=[O:41])[C:34]3[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=3)=[CH:29][CH:28]=2)=[C:21]([Cl:42])[CH:20]=1)[C:10]([NH:12][CH2:13]C(OC)OC)=[O:11])C1C=CC=CC=1.Cl>C(#N)C>[Cl:40][C:37]1[CH:36]=[CH:35][C:34]([C:33]([C:30]2[CH:29]=[CH:28][C:27]([CH2:26][C:22]3[C:23]([Cl:25])=[CH:24][C:19]([N:9]4[C:10](=[O:11])[NH:12][CH2:13][CH:1]=[N:8]4)=[CH:20][C:21]=3[Cl:42])=[CH:32][CH:31]=2)=[O:41])=[CH:39][CH:38]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 541611281-Benzylidene-2-{4-[4-(4-chlorobenzoyl)benzyl]-3,5-dichlorophenyl}-4-(2,2-dimethoxy)ethyl semicarbazide

Product 1

HCID 216994142-{4-[4-(4-chlorobenzoyl)benzyl]-3,5-dichlorophenyl}-4,5-dihydro-1,2,4-triazin-3(2H)-oneYield 96%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In 12 ml of acetonitrile was suspended 0.90 g of 1-benzylidene-2-{4-[4-(4-chlorobenzoyl)benzyl]-3,5-dichlorophenyl}-4-(2,2-dimethoxy)ethyl semicarbazide, and 0.15 g of conc. hydrochloric acid was added. The mixture was reacted at 20 to 25° C. for 1 hour, and precipitated crystals were collected by filtration to give the above-identified compound as colorless crystals (yield: 96%).

Workup

  1. additionwas added
  2. customThe mixture was reacted at 20 to 25° C. for 1 hour
  3. customprecipitated crystals
  4. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-f3d01c53750e4dc38960b87a7630ffa9
Source dataset
uspto-grants-1999_11
Patent number
US05985875

Reaction notes

Loading…