HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1602946Generated: October 25, 2026
Methyl 4-aminobenzoate → Diethyl 2-butyl-3-[(4-(methoxycarbonyl)-phenyl)-amino]-2-butenedioate
https://huagongshe.com/reaction/1602946
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 4-aminobenzoate | HCID 12082 | — |
| Reactant | Diethyl 2-butyl-3-oxobutanedioate | HCID 251159 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | Diethyl 2-butyl-3-[(4-(methoxycarbonyl)-phenyl)-amino]-2-butenedioate | HCID 67577966 | 100.8% |
Reaction Steps
27.8 g of methyl 4-aminobenzoate and 47 g of diethyl 2-butyl-3-oxo-butanedioate were mixed and 2 g of activated siliporite were added. The mixture was stirred for about 30 hours at 60° C. and after chromatography (eluant: hexane-ethyl acetate 95-5), 70 g of the expected product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05985894 |
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| Source dataset | uspto-grants-1999_11 |
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| ORD ID | ord-bf78c89fb387424f95711f87e8397512 |
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| Source note | uspto-grants-1999_11 |
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