3,6-Dimethoxyfluoren-9-one → HCID 18394938, compound

HRID 1602956Notes

Reaction equation

HRID 1602956 reaction equation
[CH3:1][C:2]([Si:5]([CH3:38])([CH3:37])[O:6][C@@H:7]1[C@H:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])[C@@H:10]([CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[O:9][C@H:8]1[N:29]1[CH:36]=[CH:35][C:33](=[O:34])[NH:32][C:30]1=[O:31])([CH3:4])[CH3:3].[CH3:39][O:40][C:41]1[CH:42]=[CH:43][C:44]2[C:45](=[O:56])[C:46]3[C:51]([C:52]=2[CH:53]=1)=[CH:50][C:49]([O:54][CH3:55])=[CH:48][CH:47]=3>>[CH3:55][O:54][C:49]1[CH:48]=[CH:47][C:46]2[C:45]([C:35]3[C:33](=[O:34])[NH:32][C:30](=[O:31])[N:29]([CH:36]=3)[C@@H:8]3[O:9][C@H:10]([CH2:20][O:21][Si:22]([C:25]([CH3:26])([CH3:27])[CH3:28])([CH3:23])[CH3:24])[C@@H:11]([O:12][Si:13]([C:16]([CH3:17])([CH3:18])[CH3:19])([CH3:14])[CH3:15])[C@H:7]3[O:6][Si:5]([C:2]([CH3:1])([CH3:3])[CH3:4])([CH3:38])[CH3:37])([OH:56])[C:44]3[C:52]([C:51]=2[CH:50]=1)=[CH:53][C:41]([O:40][CH3:39])=[CH:42][CH:43]=3

Participants

3

Reactant 2

HCID 2579393,6-Dimethoxyfluoren-9-oneHCID 10841090o,o,o-Tris(tert-butyldimethylsilyl)uridine

Product 1

HCID 18394938HCID 18394938, compound

Procedure

5-(3,6-Dimethoxy-9-hydroxyfluoren-9-yl)-2',3',5'-tris-O-((1,1-dimethylethyl)dimethylsilyl)uridine was prepared from 2',3',5'-tris-O-((1,1-dimethylethyl)dimethylsilyl)uridine according to the method of Example 1 step (i) (using 3,6-dimethoxyfluoren-9-one (J. Org. Chem. (1993) 58 (16), 4398-4404) instead of benzophenone) as a pale yellow solid.

Sources & evidence

ORD record
ord-8e1028a7868e4816a01a526332bfbb9e
Source dataset
uspto-grants-1999_11
Patent number
US05985849

Reaction notes

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