3-Phenoxybenzaldehyde → HCID 54398332, compound

HRID 1602972Notes

Reaction equation

[CH3:1][C:2]([Si:5]([CH3:38])([CH3:37])[O:6][C@@H:7]1[C@H:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])[C@@H:10]([CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[O:9][C@H:8]1[N:29]1[CH:36]=[CH:35][C:33](=[O:34])[NH:32][C:30]1=[O:31])([CH3:4])[CH3:3].[O:39]([C:46]1[CH:47]=[C:48]([CH:51]=[CH:52][CH:53]=1)[CH:49]=[O:50])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1>>[OH:50][CH:49]([C:48]1[CH:51]=[CH:52][CH:53]=[C:46]([O:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH:47]=1)[C:35]1[C:33](=[O:34])[NH:32][C:30](=[O:31])[N:29]([CH:36]=1)[C@@H:8]1[O:9][C@H:10]([CH2:20][O:21][Si:22]([C:25]([CH3:26])([CH3:27])[CH3:28])([CH3:23])[CH3:24])[C@@H:11]([O:12][Si:13]([C:16]([CH3:17])([CH3:18])[CH3:19])([CH3:14])[CH3:15])[C@H:7]1[O:6][Si:5]([C:2]([CH3:1])([CH3:3])[CH3:4])([CH3:38])[CH3:37]

Participants

Reactant 2

HCID 382843-Phenoxybenzaldehyde

HCID 10841090o,o,o-Tris(tert-butyldimethylsilyl)uridine

Product 1

HCID 54398332HCID 54398332, compound

Procedure

5-(Hydroxy-((3-phenoxy)phenyl)methyl)-2',3',5'-tris-O-((1,1-dimethylethyl)dimethylsilyl)uridine was prepared from 2',3',5'-tris-O-((1,1-dimethylethyl)dimethylsilyl)uridine according to the method of Example 1 step (i) (using 3-phenoxybenzaldehyde instead of benzophenone) as a colourless foam.

Sources & evidence

ORD record: ord-3c39119e598b49a99c1403dc92f7851d
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05985849

Reaction notes

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