Water → HCID 86754804, compound

HRID 1603027Notes

Reaction equation

HRID 1603027 reaction equation
[CH2:1]([C:8]1[CH:17]=[CH:16][C:11]([O:12][CH2:13][C:14]#[N:15])=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Cl.[NH2:19][OH:20].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[CH2:1]([C:8]1[CH:17]=[CH:16][C:11]([O:12][CH2:13][C:14](=[N:19][OH:20])[NH2:15])=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

6

Reactant 4

HCID 962Water2×HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 19608757HCID 19608757, compound

Product 1

HCID 86754804HCID 86754804, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

30.6 g (0.13 mol) of 4-n-heptyl-phenoxy-acetonitrile, 18.1 g (0.26 mol) of hydroxylamine hydrochloride and 27.6 g (0.26 mol) of sodium carbonate are stirred at reflux temperature in 100 ml of ethanol and 200 ml of water until the reaction is complete (approximately 24 hours). The entire reaction batch is subsequently introduced into water, and the mixture is extracted using methylene chloride. 34.3 g (99.8% of theory) of 4-n-heptyl-phenoxy-acetamide oxime are obtained.

Workup

  1. custom(approximately 24 hours)
  2. extractionthe mixture is extracted

Sources & evidence

ORD record
ord-9885c58ee1c147f49905696555169fc4
Source dataset
uspto-grants-1999_11
Patent number
US05985904

Reaction notes

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