反应详情

To a stirred solution of 4-[4-(2-benzyloxyethyl)phenyl]-4H-[1,2,4]triazole (0.237 g in 20 mL methanol) was added 183 mg of 10% palladium hydroxide on carbon catalyst followed by 0.20 mL acetic acid. The reaction flask was fitted with a hydrogen balloon, evacuated and recharged with hydrogen (3 times) and stirred at room temperature. After 11 hours the reaction was flushed with nitrogen, filtered over diatomaceous earth and concentrated in vacuo. Purification by flash chromatography (methylene chloride:methanol:ammonium hydroxide, 90:7:1) gave the title compound (0.147 g).

1. customevacuated
2. customAfter 11 hours the reaction was flushed with nitrogen
3. filtrationfiltered over diatomaceous earth
4. concentrationconcentrated in vacuo
5. customPurification by flash chromatography (methylene chloride:methanol:ammonium hydroxide, 90:7:1)