Dichloromethane → N-(6-Bromo-5-methoxypyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide

HRID 160317Notes

Reaction equation

HRID 160317 reaction equation
[Br:1][c:2]1[c:3]([O:9][CH3:10])[cH:4][cH:5][c:6]([NH2:8])[n:7]1.[CH3:11][CH2:12][N:13]([CH2:14][CH3:15])[CH2:16][CH3:17].[Cl:35][CH2:36][Cl:37].[F:18][C:19]1([F:34])[O:20][c:21]2[c:22]([cH:24][cH:25][c:26]([C:28]3([C:31](=[O:32])[Cl:33])[CH2:29][CH2:30]3)[cH:27]2)[O:23]1>>[Br:1][c:2]1[c:3]([O:9][CH3:10])[cH:4][cH:5][c:6]([NH:8][C:31]([C:28]2([c:26]3[cH:25][cH:24][c:22]4[c:21]([cH:27]3)[O:20][C:19]([F:18])([F:34])[O:23]4)[CH2:29][CH2:30]2)=[O:32])[n:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 127582096-Bromo-5-methoxypyridin-2-amineHCID 575168501-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl chloride

Product 1

HCID 59165869N-(6-Bromo-5-methoxypyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-6f785e198d1a47afb7d71babb804a2cc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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