反应详情

2-Bromo4-chlorobutyryl bromide (BCBB, 145.7 g, 0.540 mole) was added via an addition funnel to a cold (5° C.), well stirred slurry of 4-aminobenzonitrile (4-ABN, 55.0 g, 0.466 mole), Na3PO4 (42 g, 0.256 mole) and acetonitrile (550 mL) in a 1 liter flask while maintaining a temperature below 30° C. during the addition. The addition funnel was rinsed with acetonitrile (55 mL). Upon completion of the coupling (determined by LC), a 50 wt % solution of NaOH (56 mL, 1.061 mole) was added via an addition funnel while maintaining the reaction temperature below 30° C. Upon completion of the reaction (determined by LC), the slurry was filtered through a pressure filter (10 micron polypropylene filter cloth). The flask and the cake were washed with acetonitrile (256 mL). The filtrate and the wash were combined to afford a solution of 4-(3-bromo-2-oxopyrrolidin-1-yl)benzonitrile in acetonitrile (of about 17 wt %). Qualitative LC analysis showed the product with 91.8 to 95 area % purity.

1. temperaturewhile maintaining a temperature below 30° C.
2. additionduring the addition
3. washThe addition funnel was rinsed with acetonitrile (55 mL)
4. temperaturewhile maintaining the reaction temperature below 30° C
5. customUpon completion of the reaction (determined by LC)
6. filtrationthe slurry was filtered through a pressure
7. filtrationfilter
8. filtration(10 micron polypropylene filter cloth)
9. washThe flask and the cake were washed with acetonitrile (256 mL)