反应详情

970 mg of 2-ethynyl-benzyl alcohol were dissolved in 50 ml of diethyl ester. 1.9 ml of triethylamine was added, followed by dropwise addition of 0.9 ml of trimethylsilyl chloride. The reaction mixture was stirred at room temperature for 4 hours, poured onto ice/5% aqueous sodium bicarbonate and extracted with ether. The oily residue obtained after drying and evaporation of the solvent was distilled to give 1.3 g of 2-ethynylbenzyl trimethylsilyl ether as a colourless oil, b.p. 85-89° C./0.8 mm.

1. additionpoured onto ice/5% aqueous sodium bicarbonate
2. extractionextracted with ether
3. customThe oily residue obtained
4. customafter drying
5. customevaporation of the solvent
6. distillationwas distilled