HRID1603402

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

2 次

HCID8314

2-Methylbutanoic acid

C5H10O2

HCID33624

(S)-Timolol

C13H24N4O3S

PRODUCTS

生成物

$结构：CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1.O=C(O)/C=C\C(=O)O$

HCID5281056

Timolol maleate salt

C17H28N4O7S

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID11192

Zinc acetate

C4H6O4Zn

PROCEDURE

实验过程

15 grams of Carbopol 974P is dispersed in 40 grams of heavy mineral oil USP and is added to 841.5 grams of water containing 2.5 grams of timolol meleate with vigorous stirring. 100 grams of water containing 1.0 gram of zinc acetate is added in a controlled fashion with homogenization to get a particle size distribution size below 5 micron.

WORKUP

后处理

customto get a particle size distribution size below 5 micron