HCID 19605030, compound → HCID 21262374, compound

HRID 1603485Notes

Reaction equation

HRID 1603485 reaction equation
C([O:4][CH2:5][C:6]1[S:10][C:9]2=[CH:11][N:12]=[CH:13][N:8]2[CH:7]=1)(=O)C>CO.C(=O)([O-])[O-].[K+].[K+]>[OH:4][CH2:5][C:6]1[S:10][C:9]2=[CH:11][N:12]=[CH:13][N:8]2[CH:7]=1

Participants

4

Reactant 1

HCID 19605030HCID 19605030, compound

Product 1

HCID 21262374HCID 21262374, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 11430Potassium CarbonateSolvent

Procedure

A 846 mg potion of 2-acetoxymethylimidazo[5,1-b]thiazole was dissolved in a mixed solution of 17 ml of methanol and 1 ml of an aqueous saturated potassium carbonate solution, followed by stirring at room temperature for 1.5 hours. Then, the reaction solution was filtered, and the filtrate was then concentrated under reduced pressure. The resulting residue was purified by a silica gel column chromatograph to obtain 550 mg of the title compound.

Workup

  1. filtrationThen, the reaction solution was filtered
  2. concentrationthe filtrate was then concentrated under reduced pressure
  3. customThe resulting residue was purified by a silica gel column chromatograph

Sources & evidence

ORD record
ord-25646c1fe70942cdaae2592f32695b16
Source dataset
uspto-grants-1999_11
Patent number
US05990101

Reaction notes

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