反应详情

A 30 mg potion of a sodium ethoxide powder was added to 6.2 ml of an allyl alcohol solution containing 314.2 mg of 3-ethoxycarbonylmethylimidazo[5,1-b]thiazole, and the mixture was then was then heated under reflux for 7 hours. After cooled, the reaction solution was concentrated under reduced pressure, and the organic layer extracted with dichloromethane (10 ml×4) was dried over anhydrous magnesium sulfate, and then filtered, and the solvent was evaporated under reduced pressure. The resulting crude product was purified by a silica gel column chromatograph to obtain 240.4 mg of the title compound as a colorless solid.

1. temperaturethe mixture was then was then heated
2. temperatureunder reflux for 7 hours
3. temperatureAfter cooled
4. concentrationthe reaction solution was concentrated under reduced pressure
5. extractionthe organic layer extracted with dichloromethane (10 ml×4)
6. dry with materialwas dried over anhydrous magnesium sulfate
7. filtrationfiltered
8. customthe solvent was evaporated under reduced pressure
9. customThe resulting crude product was purified by a silica gel column chromatograph