HCID 19605067, compound → HCID 19605222, compound

HRID 1603496Notes

Reaction equation

HRID 1603496 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]2=[CH:11][N:12]=[CH:13][N:8]2[CH:7]=1)=O)C.[NH3:14].CO>>[C:4]([C:6]1[S:10][C:9]2=[CH:11][N:12]=[CH:13][N:8]2[CH:7]=1)(=[O:3])[NH2:14]

Participants

3

Reactant 2

HCID 19605067HCID 19605067, compoundHCID 21705897Ammonia methanol

Product 1

HCID 19605222HCID 19605222, compound

Procedure

A 294 mg potion of 2-ethoxycarbonylimidazo[5,1-b]thiazole was dissolved in 8 ml of a 2M ammonia/methanol solution, and the mixture was then stirred at room temperature for 4 days. After concentration under reduced pressure, 3 ml of dichloromethane was added to the resulting residue, and the precipitate was collected by filtration, washed with dichloromethane, and then dried under reduced pressure to obtain 226 mg of the title compound.

Workup

  1. concentrationAfter concentration under reduced pressure, 3 ml of dichloromethane
  2. additionwas added to the resulting residue
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with dichloromethane
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-5aec2c9db16642699d99be4294006eed
Source dataset
uspto-grants-1999_11
Patent number
US05990101

Reaction notes

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