HCID 19605759, compound → 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethyl-quinazoline

HRID 1603527Notes

Reaction equation

HRID 1603527 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]#[C:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[CH2:23][CH3:24]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][CH2:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[CH2:23][CH3:24]

Participants

4

Reactant 1

HCID 19605759HCID 19605759, compound

Product 1

HCID 99490646-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethyl-quinazoline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

150 mg of 6-[2-(2,5-dimethoxyphenyl)ethynyl]-4-ethyl-quinazoline are dissolved in 10 ml of ethyl acetate. After addition of 20 mg of palladium (10% on charcoal) the mixture is stirred overnight under an atmosphere of hydrogen and subsequently filtered over celite. The filtrate is evaporated in vacuo and the residue crystallised from cylohexane to obtain the title compound as colourless crystals. mp: 74°.

Workup

  1. filtrationsubsequently filtered over celite
  2. customThe filtrate is evaporated in vacuo
  3. customthe residue crystallised from cylohexane

Sources & evidence

ORD record
ord-cc9ba045d0294a579aae97e17a56de20
Source dataset
uspto-grants-1999_11
Patent number
US05990116

Reaction notes

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