Methyl iodide → HCID 19605774, compound

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Reaction Steps

34 mg of 6-[2-(2,5-dimethoxyphenyl)ethyl]-4-quinazolinone are dissolved in 4 ml of dimethylformamide and treated with 4 mg of sodium hydride (80% in mineral oil). After stirring for 30 minutes, 0.1 ml of methyl iodide are added, and stirring is continued for 1 hour. The mixture is poured onto water and extracted with ethyl acetate. The combined organic layers are dried over magnesium sulfate and concentrated in vacuo. Silica gel chromatography (cyclohexane/ethyl acetate=1/2) of the residue gives the title compound as colourless crystals. mp: 83-85°.

Provenance & Evidence