反应详情

34 mg of 6-[2-(2,5-dimethoxyphenyl)ethyl]-4-quinazolinone are dissolved in 4 ml of dimethylformamide and treated with 4 mg of sodium hydride (80% in mineral oil). After stirring for 30 minutes, 0.1 ml of methyl iodide are added, and stirring is continued for 1 hour. The mixture is poured onto water and extracted with ethyl acetate. The combined organic layers are dried over magnesium sulfate and concentrated in vacuo. Silica gel chromatography (cyclohexane/ethyl acetate=1/2) of the residue gives the title compound as colourless crystals. mp: 83-85°.

1. stirringstirring
2. waitis continued for 1 hour
3. additionThe mixture is poured onto water
4. extractionextracted with ethyl acetate
5. dry with materialThe combined organic layers are dried over magnesium sulfate
6. concentrationconcentrated in vacuo