反应详情

87 mg of 5-[2-(2,5-dimethoxyphenyl)ethyl]-2-acetylamino benzoic acid methylester are dissolved in 6 ml of methanol, treated with 1 ml of 4 N hydrochloric acid and stirred for 48 hours at room temperature. The mixture is neutralised by addition of 2 N aqueous sodium hydroxide solution and extracted with ethyl acetate. The combined organic layers are dried over magnesium sulfate and concentrated in vacuo. Purification by chromatography on silica gel (hexane/ethyl acetate=6/1) yields the title compound as colourless crystals. mp: 50-55°.

1. extractionextracted with ethyl acetate
2. dry with materialThe combined organic layers are dried over magnesium sulfate
3. concentrationconcentrated in vacuo
4. customPurification by chromatography on silica gel (hexane/ethyl acetate=6/1)