Ammonium Hydroxide → 6-Iodoquinazolin-4-amine

HRID 1603541Notes

Reaction equation

HRID 1603541 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[OH-].[NH4+:14]>>[NH2:14][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 111738094-Chloro-6-iodoquinazoline

Product 1

HCID 196057666-Iodoquinazolin-4-amine

Procedure

500 mg of 4-chloro-6-iodo-quinazoline are treated with 30 ml of aqueous ammonium hydroxide solution and heated to reflux for 2 hours. After cooling the precipitated title compound is filtered and dried.

Workup

  1. temperatureheated
  2. temperatureto reflux for 2 hours
  3. temperatureAfter cooling the
  4. customprecipitated title compound
  5. filtrationis filtered
  6. customdried

Sources & evidence

ORD record
ord-ce74868f0f2841bdb8a5e506111a583a
Source dataset
uspto-grants-1999_11
Patent number
US05990116

Reaction notes

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