4-Methoxybenzaldehyde → HCID 178491244, compound

HRID 1603675Notes

Reaction equation

HRID 1603675 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([NH:11][NH2:12])[N:3]=1.[CH:13](=O)[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1>C(O)(=O)C>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([NH:11][N:12]=[CH:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[N:3]=1

Participants

4

Reactant 2

HCID 312444-MethoxybenzaldehydeHCID 178514355HCID 178514355, compound

Product 1

HCID 178491244HCID 178491244, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-Amino-6-hydrazino-9H-purine (1.0 g, 6.1 mmol) and p-anisaldehyde (1.24 g, 9.1 mmol) were added to acetic acid (40 ml), and the mixture was stirred for 4 hours at room temperature. After completion of reaction, the solvent was evaporated under reduced pressure so as to precipitate solid crystals. The crystals were recrystallized from DMF to obtain 1.13 g (yield 66%) of colorless powdery crystals (m.p.=174° C. (decomposed)).

Workup

  1. customAfter completion of reaction
  2. customthe solvent was evaporated under reduced pressure so as
  3. customto precipitate solid crystals
  4. customThe crystals were recrystallized from DMF

Sources & evidence

ORD record
ord-392ca0aaaed64ac69cf307e5088536d0
Source dataset
uspto-grants-1999_11
Patent number
US05990118

Reaction notes

Loading…