Hydrazine hydrate (1:1) → HCID 178514361, compound

HRID 1603676Notes

Reaction equation

HRID 1603676 reaction equation
[O:1]=[C:2]1[NH:10][C:9]2[NH:8][CH:7]=[N:6][C:5]=2[C:4](=S)[NH:3]1.O.[NH2:13][NH2:14]>>[NH:13]([C:4]1[C:5]2[N:6]=[CH:7][NH:8][C:9]=2[NH:10][C:2](=[O:1])[N:3]=1)[NH2:14]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178518759HCID 178518759, compound

Product 1

HCID 178514361HCID 178514361, compoundYield 63%

Conditions

Temperature
120 °C

Procedure

2-Oxo-6-thioxo-1,2,3,6-tetrahydro-9H-purine (J. Am. Chem. Soc., 76, 5633 (1954)) (0.5 g, 2.97 mmol) was added to 80% hydrazine hydrate (5 ml), and the mixture was stirred for 10 minutes at 120° C. After completion of reaction, crystals that precipitated were collected by filtration, and washed with water. The crystals were recrystallized from water to obtain 0.31 g (yield 63%) of colorless powdery crystals (m.p.=278° C. (decomposed)).

Workup

  1. customAfter completion of reaction, crystals that
  2. customprecipitated
  3. filtrationwere collected by filtration
  4. washwashed with water
  5. customThe crystals were recrystallized from water

Sources & evidence

ORD record
ord-84a4fbff71ff4cc8a97d737852cbde47
Source dataset
uspto-grants-1999_11
Patent number
US05990118

Reaction notes

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